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KMID : 0043319940170040244
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Archives of Pharmacal Research
1994 Volume.17 No. 4 p.244 ~ p.248
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Chiral Separation of Salbutamol Enantiomers in Human Plasma
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Seo Joung-Min
Kim Kyeong-Ho
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Abstract
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A stereoselective and sensitive high performance liquid chromatography using fluoresecence deterctor was examined for the determination of R(-) and S(+)-salbutamol in human plasma. Solid phase extraction method using silica as sorbent was used to extract salbutamol racemates from the plasma matrices. After fractionation and freeze-drying of the eluates containing salbutamol racemates, they were separated and quantified on a chirla stationary column. The detection limit of each enantiomer was 2 ng/ml in human plasma (S/N=3).
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KEYWORD
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Enantimmer, Salbutamol, Solid phase extration
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